This review examines current evidence about treatments for opioid dependence, comparing methadone with naltrexone-based approaches. Research from clinical trials and long-term studies reveals important concerns about safety and effectiveness of traditional treatments. Evidence suggests that naltrexone treatment for opioid dependence may offer better outcomes for people seeking to overcome addiction and achieve drug-free recovery.
Naltrexone-Based Treatments: A Path to Drug-Free Recovery
Current evidence strongly suggests that naltrexone-based treatments offer significant advantages over methadone for most outcomes, including:
- Lower risk of fatal overdose during and after treatment
- Greater reduction in illicit drug use
- Better support for achieving lasting abstinence
- Avoiding continued dependence on opioids
- Potential reversal of addiction-related brain changes
While methadone programs focus on keeping patients in treatment indefinitely, naltrexone approaches aim for drug-free recovery and normal brain function—a fundamental difference in treatment philosophy.
