Association of 1 Vaping Session With Cellular Oxidative Stress in Otherwise Healthy Young People With No History of Smoking or Vaping-A Randomized Clinical Crossover Trial

A single 30-minute vaping session can significantly increase cellular oxidative stress. Middlekauff et al demonstrated that vaping is associated with adverse changes in the body that can presage future health problems

Like tobacco cigarette (TCIG) smoking, long-term electronic cigarette (ECIG) vaping in young people is associated with elevated cellular oxidative stress (COS), which is important in the pathogenesis of many diseases, including atherosclerosis.¹ As with TCIG smoking,² even infrequent ECIG use may be associated with adverse biological effects with implications for future health risks. Importantly, the proportion of high school students who have used ECIGs within 1 month of the time of study has skyrocketed, approaching 30% in the US.^3,4 The purpose of this study was to evaluate the association of a single session of ECIG vaping on COS in immune cells in young people who do not smoke or vape compared with young people with long-term TCIG or ECIG use.

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