Published: October 18, 202 3DOI:https://doi.org/10.1016/j.jpain.2023.10.009
Highlights
- CBD products may have varying amounts of CBD, varying from none to much more than advertised.
- CBD products may contain other chemicals than CBD, some of which may be harmful.
- 16 RCTs for pain used pharmaceutical CBD in oral, buccal/sublingual, and topical forms.
- 15 of the 16 RCTs were negative: no greater pain-relieving effect for CBD than for placebo.
- Meta-analyses link CBD to increased rates serious adverse events and hepatotoxicity.
Small clinical trials using verified CBD suggest the drug to be largely benign; while large scale evidence of safety is lacking there is growing evidence linking CBD to increased rates of serious adverse events and hepatotoxicity.
There is no good reason for thinking that CBD relieves pain, but there are good reasons for doubting the contents of CBD products in terms of CBD content and purity.
(for complete research The Journal of Pain – (US Association for Study of Pain, USASP)
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