Pennsylvania legalized medical marijuana in 2016, and since then its use has skyrocketed.1 The doses of the active ingredients of marijuana — tetrahydrocannabinol (THC) and cannabidiol (CBD) — are not standardized, product concentrations are not regulated, and prescribing practices vary…
Neurotoxic effects, ranging from central nervous system (CNS) excitation (anxiety, paranoia, and delirium) to CNS depression, are a well-described consequence of exposure to excessive amounts of cannabinoids, with excitation more common in adults and depression more common in children.2 For the formulation that our patient used, each 0.1 ml of fluid was reported to contain 50 mg of THC, 10 to 20 times as great as the doses recommended for therapeutic use.3 A typical recreational dose of THC for persons who have not previously used marijuana is 10 mg.
